NFKBID

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Description

The NFKBID (NFKB inhibitor delta) is a protein-coding gene located on chromosome 19.

NFKBID is a protein that inhibits the activity of the transcription factor NF-κB, which is involved in regulating the expression of genes related to immune responses and inflammation. NFKBID is a member of the atypical inhibitors of NF-κB, meaning it acts on NF-κB in the nucleus of the cell rather than in the cytoplasm. NFKBID is a nuclear protein with 327 amino acids. It contains six ankyrin repeats (ANKs), which are characteristic of all IκB proteins. These repeats are surrounded by a nuclear localization signal sequence (NLS) at the N-terminus and a short C-terminus. NFKBID's role in regulating NF-κB activity is important for the body's response to various stimuli, including stress and bacterial or viral antigens.

NFKBID is also known as IkBNS, IkappaBNS, TA-NFKBH.

Associated Diseases

• common variable immunodeficiency
• combined immunodeficiency with skin granulomas
• severe combined immunodeficiency due to CARD11 deficiency
• isolated agammaglobulinemia
• classic Hodgkin lymphoma
• BENTA disease
• hyper-IgM syndrome type 3
• immunodeficiency 18
• immune deficiency, familial variable
• immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia
• immunodeficiency 62
• severe combined immunodeficiency due to CTPS1 deficiency
• immunodeficiency 105
• immunodeficiency, common variable, 14
• agammaglobulinemia 10, autosomal dominant
• short-limb skeletal dysplasia with severe combined immunodeficiency
• immunodeficiency, common variable, 4
• immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias