NFIL3
Description
The NFIL3 (nuclear factor, interleukin 3 regulated) is a protein-coding gene located on chromosome 9.
NFIL3, also known as E4BP4, is a protein encoded by the NFIL3 gene in humans. It is involved in regulating the expression of interleukin-3 (IL-3), a cytokine that is produced by activated T cells, natural killer (NK) cells, and mast cells. NFIL3 binds to specific regions of the IL-3 gene, promoting transcription initiation.
NFIL3 is a transcriptional regulator that binds to a specific DNA sequence (5'-[GA]TTA[CT]GTAA[CT]-3') found in various cellular and viral promoters. It can repress transcription from promoters containing activating transcription factor (ATF) sites, including those in osteoblasts, PER1, and PER2. Conversely, NFIL3 activates transcription from the interleukin-3 promoter in T-cells. It competes for binding sites with PAR DNA-binding factors such as DBP, HLF, and TEF. As part of the circadian clock, NFIL3 negatively regulates the rhythmic expression of PER2. Additionally, NFIL3 protects pro-B cells from apoptosis, represses CYP2A5 transcription, and positively regulates CES2 expression by counteracting the inhibitory effects of NR1D1. It is crucial for the development of natural killer cell precursors.
NFIL3 is also known as E4BP4, IL3BP1, NF-IL3A, NFIL3A.
