NFATC4
Description
The NFATC4 (nuclear factor of activated T cells 4) is a protein-coding gene located on chromosome 14.
Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene.
== Function == The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4.
== Interactions == NFATC4 has been shown to interact with CREB-binding protein.
== See also == NFAT
== References ==
== Further reading ==
== External links == NFATC4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
NFATC4 is a calcium-regulated transcription factor involved in various biological processes, including immune system development and function, cardiovascular system development and function, musculoskeletal system development, and nervous system development and function. It plays a key role in T-cell activation by stimulating the transcription of cytokine genes, including IL2 and IL4. Along with NFATC3, NFATC4 participates in embryonic heart development. It activates transcription in cardiomyocytes by binding to the alpha-beta E4 promoter region of CRYAB, following JAK/STAT signaling activation and forming a complex with NFATC3 and STAT3. It is also involved in mitochondrial energy metabolism essential for cardiac morphogenesis and function. NFATC4 regulates numerous genes involved in the cardiovascular system, including AGTR2, NPPB/BNP, NPPA/ANP/ANF, and MYH7/beta-MHC. NFATC4 participates in the regulation of adult hippocampal neurogenesis, contributing to BDNF-driven pro-survival signaling in adult-born neurons, and is involved in the formation of long-term spatial memory and long-term potentiation. In cochlear nucleus neurons, NFATC4 may play a role in deafferentation-induced apoptosis during the developmental critical period. NFATC4 activates the BACE1/Beta-secretase 1 promoter, potentially regulating the proteolytic processing of the amyloid precursor protein (APP). NFATC4 also contributes to adipocyte differentiation and may be involved in myoblast differentiation into myotubes. It binds to the consensus DNA sequence 5'-GGAAAAT-3' and activates TNF transcription in the presence of CREBBP. NFATC4 regulates the activity of the PPARG gene promoter and binds to PPARG and REG3G gene promoters.
NFATC4 is also known as NF-AT3, NF-ATC4, NFAT3.
