NEU4

Description

The NEU4 (neuraminidase 4) is a protein-coding gene located on chromosome 2.

NEU4 gene encodes for sialidase-4, an enzyme involved in the removal of sialic acid residues from glycoproteins and glycolipids. It belongs to a family of glycohydrolytic enzymes. Sialidase-4 has been shown to interact with phospholipid scramblase 1.

NEU4, also known as N-acetyl-alpha-neuraminidase 4, is an exo-alpha-sialidase that removes sialic acid (N-acetylneuraminic acid, Neu5Ac) from the ends of glycans. This enzyme plays a role in breaking down glycolipids, glycoproteins, and oligosaccharides. NEU4 efficiently breaks down gangliosides, including GD1a and GM3 (alpha-(2->3)-sialylated) and GD3 (alpha-(2->8)-sialylated). It also hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule (NCAM1), likely at growth cones, which inhibits neurite outgrowth in hippocampal neurons. NEU4 may also remove sialic acid from sialyl Lewis A and X antigens on the cell surface, reducing the recognition of these glycan epitopes by SELE/E selectin, which is involved in cell adhesion and extravasation. NEU4 has sialidase activity towards mucin, fetuin, and sialyllactose.

NEU4 is also known as -.

Associated Diseases

WES Whole Exome Sequencing