NEK3
Description
The NEK3 (NIMA related kinase 3) is a protein-coding gene located on chromosome 13.
NEK3 (NIMA-related kinase 3) is a human gene that encodes a serine/threonine-protein kinase. This kinase is similar in sequence to the Aspergillus nidulans protein NimA (never in mitosis A), which is involved in cell cycle regulation. NEK3 may play a role in mitotic regulation, but unlike other NimA family members, it is not cell cycle regulated and is primarily located in the cytoplasm. Three transcript variants have been identified for NEK3, but only two have been fully characterized.
NEK3 is a protein kinase that influences neuronal morphogenesis and polarity by affecting microtubules. It regulates microtubule acetylation in neurons. NEK3 contributes to prolactin-mediated phosphorylation of PXN and VAV2, playing a role in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.
NEK3 is also known as HSPK36.
Associated Diseases
- hereditary breast ovarian cancer syndrome
- cancer
- hyperinsulinemic hypoglycemia, familial, 4
- breast cancer
- Fanconi renotubular syndrome
- disorder of glycogen metabolism
