NEK11
Description
The NEK11 (NIMA related kinase 11) is a protein-coding gene located on chromosome 3.
NEK11 is a protein kinase that plays a critical role in the G2/M checkpoint response to DNA damage. It controls the degradation of CDC25A by directly phosphorylating it on specific residues. This phosphorylation is essential for BTRC-mediated polyubiquitination and subsequent degradation of CDC25A.
NEK11 is also known as -.
Associated Diseases
- breast cancer
- hemochromatosis type 5
- hyperinsulinism due to glucokinase deficiency
- hyperinsulinism due to INSR deficiency
- exercise-induced hyperinsulinism
- aceruloplasminemia
- glycogen storage disorder due to hepatic glycogen synthase deficiency
- 3-hydroxy-3-methylglutaryl-CoA synthase deficiency
