NECAB2

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Description

The NECAB2 (N-terminal EF-hand calcium binding protein 2) is a protein-coding gene located on chromosome 16.

NECAB2, or N-terminal EF-hand calcium-binding protein 2, is a protein encoded by the NECAB2 gene in humans.

NECAB2 acts as a signaling scaffold protein that senses intracellular calcium. It can modulate the internalization of ADORA2A receptors following ligand binding, as well as regulate the coupling efficiency of mGluR5/GRM5 receptors. For both receptor types, NECAB2 can influence signaling activity by promoting the activation of MAPK1/3 (ERK1/2).

NECAB2 is also known as EFCBP2, stip-2.

Associated Diseases

• male infertility with teratozoospermia due to single gene mutation
• plasma fibronectin deficiency
• partial chromosome Y deletion
• spermatogenic failure 20
• spermatogenic failure 51
• isolated asymptomatic elevation of creatine phosphokinase
• spermatogenic failure 72
• spermatogenic failure 24
• spermatogenic failure 27
• spermatogenic failure 46
• spermatogenic failure 18
• spermatogenic failure, X-linked, 3
• spermatogenic failure 42