NECAB2
Description
The NECAB2 (N-terminal EF-hand calcium binding protein 2) is a protein-coding gene located on chromosome 16.
NECAB2, or N-terminal EF-hand calcium-binding protein 2, is a protein encoded by the NECAB2 gene in humans.
NECAB2 acts as a signaling scaffold protein that senses intracellular calcium. It can modulate the internalization of ADORA2A receptors following ligand binding, as well as regulate the coupling efficiency of mGluR5/GRM5 receptors. For both receptor types, NECAB2 can influence signaling activity by promoting the activation of MAPK1/3 (ERK1/2).
NECAB2 is also known as EFCBP2, stip-2.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- plasma fibronectin deficiency
- partial chromosome Y deletion
- spermatogenic failure 20
- spermatogenic failure 51
- isolated asymptomatic elevation of creatine phosphokinase
- spermatogenic failure 72
- spermatogenic failure 24
- spermatogenic failure 27
- spermatogenic failure 46
- spermatogenic failure 18
- spermatogenic failure, X-linked, 3
- spermatogenic failure 42
