NDUFB7
Description
The NDUFB7 (NADH:ubiquinone oxidoreductase subunit B7) is a protein-coding gene located on chromosome 19.
NDUFB7, also known as Complex I-B18, is an enzyme encoded by the NDUFB7 gene. This protein is an accessory subunit of the NADH dehydrogenase (ubiquinone) complex, located in the mitochondrial inner membrane. It is part of Complex I, the largest of the five complexes in the electron transport chain. The NDUFB7 gene resides on the p arm of chromosome 19, spanning 6,000 base pairs. The protein weighs 16.4 kDa and consists of 137 amino acids. It features an L-shaped structure with a hydrophobic transmembrane domain and a hydrophilic domain. NDUFB7 and NDUFB8 are positioned at the intermembrane surface of Complex I. The hydrophobic domain acts as an anchor for the NADH dehydrogenase (ubiquinone) complex within the inner mitochondrial membrane. NDUFB7 is not directly involved in catalysis but plays a crucial role in the multisubunit NADH:ubiquinone oxidoreductase (complex I), which consists of 45 different subunits in mammals.
NDUFB7 is also known as B18, CI-B18, MC1DN39.
