NDUFB5

Description

The NDUFB5 (NADH:ubiquinone oxidoreductase subunit B5) is a protein-coding gene located on chromosome 3.

NDUFB5, encoded by the NDUFB5 gene on chromosome 3, produces a 21.7 kDa protein that is a subunit of NADH dehydrogenase (ubiquinone), the largest of the five respiratory chain complexes located in the mitochondrial inner membrane. The NDUFB5 gene spans 19,713 base pairs and encodes a protein with a hydrophobic transmembrane domain and a hydrophilic domain. The hydrophobic domain anchors the protein to the inner mitochondrial membrane, while the hydrophilic domain interacts with other subunits of Complex I. Although NDUFB5 is a component of Complex I, it is not believed to be directly involved in the catalytic transfer of electrons from NADH to ubiquinone.

NDUFB5 is also known as CISGDH, SGDH.

Associated Diseases

• type 2 diabetes mellitus
• type 1 diabetes mellitus
• schizophrenia
• breast cancer
• bipolar disorder
• urinary bladder carcinoma
• prostate cancer