NDST4
Description
The NDST4 (N-deacetylase and N-sulfotransferase 4) is a protein-coding gene located on chromosome 4.
NDST4 is a crucial enzyme involved in the biosynthesis of heparin and heparan sulfate. It catalyzes both the N-deacetylation and N-sulfation of glucosamine (GlcNAc) residues within the glycosaminoglycan chain. This dual activity modifies the repeating GlcNAc-GlcA disaccharide backbone, generating N-sulfated heparosan. This modified structure serves as the essential foundation for further modifications during heparin synthesis.
NDST4 is also known as N-HSST, N-HSST 4, NDST-4, NHSST4.
Associated Diseases
- Hirschsprung disease
- chronic intestinal pseudoobstruction
- AXIN2-related attenuated familial adenomatous polyposis
- Lynch syndrome
- colorectal cancer, susceptibility to, 3
- familial adenomatous polyposis 2
- inflammatory bowel disease 30
- hereditary mixed polyposis syndrome
- familial visceral myopathy
- microvillus inclusion disease
- NK-cell enteropathy
