NDP : norrin cystine knot growth factor NDP


The NDP Gene and Norrin: Unraveling the Secrets of Cellular Signaling and Development

Description:

The NDP gene holds the blueprint for creating norrin, a protein crucial for guiding cellular interactions and tissue formation during development. Norrin orchestrates intricate signaling pathways, influencing cell division, adhesion, migration, and a multitude of other cellular processes.

Associated Diseases:

Mutations in the NDP gene have been linked to developmental disorders, including:

  • Norrie disease: A rare genetic condition characterized by severe visual impairment or blindness due to abnormal blood vessel development in the eyes.
  • Familial exudative vitreoretinopathy (FEVR): A genetic condition causing abnormal blood vessel formation in the eyes, leading to vision problems.
  • Senior-Løken syndrome: A rare disorder that affects the eyes, ears, and endocrine system.

Did you Know ?

Norrin is a highly specific ligand, binding exclusively to frizzled-4 among the numerous frizzled receptors. This selectivity ensures precise signaling and avoids unwanted interactions.


Disclaimer: The information provided here is not exhaustive by any means. Always consult your doctor or other qualified healthcare provider with any questions you may have regarding a medical condition, procedure, or treatment, whether it is a prescription medication, over-the-counter drug, vitamin, supplement, or herbal alternative.