NDNL2
NDR2: A Vital Guardian of Neuronal Health
Description:
NDR2 (Nuclear DBF2-Related Kinase 2) is a serine/threonine protein kinase that plays a crucial role in various cellular processes, including neuronal development, synaptic plasticity, and cell survival. It is localized primarily in the nucleus and cytoplasm and is involved in regulating several signaling pathways essential for neuronal function.
Associated Diseases:
Dysregulation of NDR2 has been implicated in several neurological disorders, including:
- Neurodegenerative diseases: NDR2 dysfunction has been linked to Alzheimer's disease due to its role in amyloid-beta processing and tau phosphorylation.
- Mood disorders: Studies have suggested that NDR2 may be involved in the pathogenesis of depression and bipolar disorder.
- Developmental disorders: Mutations in the NDR2 gene have been associated with microcephaly, a condition involving abnormally small head size.
- Neurodevelopmental disorders: NDR2 has been implicated in autism spectrum disorder and intellectual disability.
Did you Know ?
Research has shown that approximately 1 in 40,000 individuals inherit a mutation in the NDR2 gene, highlighting the gene's importance in neurological health.
