NDFIP2
Description
The NDFIP2 (Nedd4 family interacting protein 2) is a protein-coding gene located on chromosome 13.
NEDD4 family-interacting protein 2 (NDFIP2) is a protein that in humans is encoded by the NDFIP2 gene. NDFIP2 has been shown to interact with NEDD4.
NDFIP2 activates various HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1, and WWP2, which influences the stability of their targets. This, in turn, plays a role in regulating diverse cellular processes. NDFIP2 facilitates the localization of ITCH, NEDD4, and SMURF2 to endosomal membranes. It negatively regulates the activity of KCNH2 potassium channel by reducing its cell surface expression and interfering with channel maturation. This occurs through NDFIP2 recruiting NEDD4L to the Golgi apparatus and multivesicular body, leading to KCNH2 degradation. NDFIP2 may also modulate EGFR signaling. In conjunction with NDFIP1, it limits cytokine signaling and the expansion of effector Th2 T-cells by promoting the degradation of JAK1, potentially through ITCH- and NEDD4L-mediated ubiquitination.
NDFIP2 is also known as N4WBP5A.
