NCOA6
Description
The NCOA6 (nuclear receptor coactivator 6) is a protein-coding gene located on chromosome 20.
Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene. The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases.
NCOA6 is a nuclear receptor coactivator that directly binds to nuclear receptors and enhances their transcriptional activity in a hormone-dependent manner. It coactivates gene expression in a way that depends on the presence of an agonist and the AF2 domain of the receptor. NCOA6 is involved in the coactivation of a variety of nuclear receptors, including those for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR), and prostanoids (PPARs). While primarily known for its role in nuclear receptor coactivation, NCOA6 may also function as a general coactivator. Additionally, NCOA6 might participate in the coactivation of the NF-kappa-B pathway. It is believed that NCOA6 can enhance gene expression by remodeling chromatin and interacting with histone acetyltransferase proteins.
NCOA6 is also known as AIB3, ASC2, NRC, PRIP, RAP250, TRBP.
Associated Diseases
- endometrial cancer
- cancer
- early-onset non-syndromic cataract
- isolated ectopia lentis
- hereditary hyperferritinemia with congenital cataracts
