NCOA4
Description
The NCOA4 (nuclear receptor coactivator 4) is a protein-coding gene located on chromosome 10.
Nuclear receptor coactivator 4, also known as Androgen Receptor Activator (ARA70), is a protein that in humans is encoded by the NCOA4 gene. It plays an important role in ferritinophagy, acting as a cargo receptor, binding to the ferritin heavy chain and latching on to ATG8 on the surface of the autophagosome.
== Interactions == NCOA4 has been shown to interact with:
Androgen receptor, and Peroxisome proliferator-activated receptor gamma Ferritin ATG8
== See also == Transcription coregulator
== References ==
== Further reading ==
== External links == NURSA C92 This article incorporates text from the United States National Library of Medicine, which is in the public domain.
NCOA4 enhances the androgen receptor transcriptional activity in prostate cancer cells and acts as a ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma.
NCOA4 is also known as ARA70, ELE1, PTC3, RFG.
Associated Diseases
- thyroid gland oncocytic adenoma
- thyroiditis
- medullary thyroid gland carcinoma
- extrarenal rhabdoid tumor
