NCK2
Description
The NCK2 (NCK adaptor protein 2) is a protein-coding gene located on chromosome 2.
NCK2 is a cytoplasmic protein encoded by the NCK2 gene in humans. It is a member of the adaptor protein family, characterized by the presence of three SH3 domains and one SH2 domain. NCK2, like its counterpart NCK1, does not possess any catalytic activity. Instead, it binds and recruits various proteins involved in the regulation of receptor protein tyrosine kinases, contributing to cytoskeletal reorganization. Multiple isoforms of NCK2 are produced through alternative splicing.
NCK2 acts as an adapter protein, binding to tyrosine-phosphorylated growth factor receptors and their associated cellular substrates. It promotes dephosphorylation of EIF2S1 by PP1, keeping its phosphorylation levels low. NCK2 also plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.
NCK2 is also known as GRB4, NCKbeta.
