NCK1-AS1
nck1-as1: A Long Non-Coding RNA with Diverse Roles in Disease
Description
nck1-as1 is a long non-coding RNA (lncRNA) located on chromosome 22q13.1. It was first identified in 2014 and has since been found to play a role in various biological processes and diseases.
lncRNAs are RNA molecules that do not code for proteins but can regulate gene expression. They can act as molecular scaffolds, binding to other molecules and bringing them together to form complexes. They can also interact with DNA or RNA to alter gene expression patterns.
nck1-as1 is one of the most studied lncRNAs, and its functions are still being elucidated. It has been shown to regulate cell proliferation, apoptosis, invasion, and migration. It is also involved in immune responses and metabolism.
Associated Diseases
Aberrant expression of nck1-as1 has been linked to several diseases, including:
- Cancer: nck1-as1 is overexpressed in many types of cancer, including breast, lung, colorectal, and gastric cancer. It promotes tumor growth, metastasis, and angiogenesis.
- Cardiovascular disease: nck1-as1 is decreased in cardiovascular disease, and its overexpression has been shown to protect against heart failure and atherosclerosis.
- Neurological disorders: nck1-as1 is involved in neurodevelopment and neuroprotection. Its dysregulation has been implicated in Alzheimer's disease, Parkinson's disease, and multiple sclerosis.
- Metabolic disorders: nck1-as1 is involved in glucose metabolism and lipid metabolism. Its dysregulation has been linked to type 2 diabetes mellitus and obesity.
Did you Know ?
A study published in the journal "Nature Genetics" found that a single nucleotide polymorphism (SNP) in the nck1-as1 gene was associated with an increased risk of breast cancer. The SNP was found to alter the binding of a microRNA (miR-122) to nck1-as1, resulting in increased expression of the lncRNA. This increased expression was associated with an increased risk of breast cancer development.
