NCK1
Description
The NCK1 (NCK adaptor protein 1) is a protein-coding gene located on chromosome 3.
NCK1 is a cytoplasmic protein encoded by the NCK1 gene. It belongs to the adaptor family of proteins and contains Src homology 2 and 3 (SH2 and SH3) domains. NCK1 acts as an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients, such as RAS. It is linked to glucose tolerance and insulin signaling in the liver of obese mice. Deletion of NCK1 causes a decrease in ER stress signaling, leading to reduced glucose tolerance and inactivation of insulin signaling in certain cell types.
NCK1 is an adapter protein that associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. It helps maintain low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. NCK1 plays a role in the DNA damage response, not in detecting the damage itself (by ATM/ATR), but in the efficient activation of downstream effectors, such as CHEK2. It is also involved in ELK1-dependent transcriptional activation in response to activated Ras signaling. NCK1 modulates the activation of EIF2AK2/PKR by dsRNA and may play a role in cell adhesion and migration through interaction with ephrin receptors.
NCK1 is also known as NCK, NCKalpha, nck-1.
