NCF1B

Description

The NCF1B (neutrophil cytosolic factor 1B (pseudogene)) is a pseudo gene located on chromosome 7.

NCF1B is a gene that encodes a protein known as p47phox. This protein is an essential component of the NADPH oxidase complex, a multi-protein enzyme system that produces reactive oxygen species (ROS) in phagocytic cells, primarily neutrophils. ROS are crucial for the killing of invading pathogens, and the NADPH oxidase complex plays a central role in the innate immune system's defense against infection. NCF1B's function is to act as an activator of the NADPH oxidase complex, enabling it to produce superoxide radicals, which are essential for the destruction of microorganisms.

NCF1B, also known as p47phox, is a crucial component of the NADPH oxidase complex, a multi-protein enzyme system vital for the production of reactive oxygen species (ROS) in phagocytic cells, particularly neutrophils. This complex plays a central role in the innate immune system, enabling the destruction of invading pathogens. NCF1B acts as an activator of the NADPH oxidase complex, enabling it to generate superoxide radicals, a form of ROS, which are essential for killing bacteria and other microorganisms. By interacting with other components of the complex, such as NOX2 and RAC1, NCF1B facilitates the assembly and activation of the NADPH oxidase, thereby promoting the production of ROS and contributing to the host's defense against infection.

NCF1B is also known as NCF-1B, SH3PXD1B.

Associated Diseases

WES Whole Exome Sequencing