NBR2
Description
The NBR2 (neighbor of BRCA1 lncRNA 2) is a ncRNA gene located on chromosome 17.
NBR2 is a gene known for its proximity to the breast cancer-associated gene BRCA1. While its connection to breast cancer is not fully understood, NBR2 has been found to act as a long non-coding RNA induced by glucose starvation. It interacts with AMP-activated protein kinase (AMPK), a key energy sensor in eukaryotic cells, and promotes AMPK activity to manage energy stress. Reducing NBR2 levels weakens AMPK activation, leading to uncontrolled cell growth, altered apoptosis and autophagy responses, and increased tumor development in living organisms. Therefore, NBR2, once considered a non-functional gene, plays a significant role in tumor suppression.
NBR2 is a gene that was initially overlooked but is now recognized for its crucial role in tumor suppression. It acts as a long non-coding RNA that is induced during glucose starvation. NBR2 interacts with AMPK, a key energy sensor, and enhances its activity to manage energy stress. When NBR2 is reduced, AMPK activation is impaired, leading to uncontrolled cell growth, abnormal apoptosis and autophagy responses, and increased tumor formation in living organisms.
NBR2 is also known as NCRNA00192.
Associated Diseases
- cancer
- Treacher-Collins syndrome
- Miyoshi myopathy
- gastrointestinal stromal tumor
- type 2 diabetes mellitus
- breast cancer
- Ehlers-Danlos syndrome, musculocontractural type
- glioblastoma
- acute liver failure
