NBR1
Description
The NBR1 (NBR1 autophagy cargo receptor) is a protein-coding gene located on chromosome 17.
NBR1 (Neighbor of BRCA1 gene 1 protein) is a protein encoded by the NBR1 gene in humans. It was initially identified as an ovarian tumor antigen, and its encoded protein contains a B-box/coiled coil motif, common in genes with transforming potential. The gene is located on chromosome 17q21.1, near the tumor suppressor gene BRCA1. Three alternatively spliced variants of the gene exist, all encoding the same protein. NBR1 is involved in autophagy, acting as a cargo receptor in selective autophagy. It interacts with FEZ1.
NBR1 is a ubiquitin-binding autophagy adapter involved in diverse cellular processes, including host defense and intracellular homeostasis. During selective autophagy, it acts as a shuttle, delivering ubiquitinated proteins to autophagosomes and also participates in the formation of protein aggregates. It regulates the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation. In response to oxidative stress, NBR1 promotes increased SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation. This activation subsequently triggers the KEAP1-NRF2/NFE2L2 antioxidant pathway. Additionally, NBR1 plays a non-autophagy role by mediating the transport of IL-12 to the late endosome for subsequent secretion.
NBR1 is also known as 1A1-3B, IAI3B, M17S2, MIG19.
Associated Diseases
- type 2 diabetes mellitus
- nonpapillary renal cell carcinoma
- type 1 diabetes mellitus
- diabetes mellitus, transient neonatal, 2
- autosomal recessive osteopetrosis 6
- hyperostosis corticalis generalisata
- autosomal dominant osteosclerosis, Worth type
- osteosclerosis-ichthyosis-premature ovarian failure syndrome
- Eiken syndrome
- melorheostosis
- hip dysplasia, Beukes type
