NAT8B
Description
The NAT8B (N-acetyltransferase 8B (putative, gene/pseudogene)) is a pseudo gene located on chromosome 2.
NAT8B is a human gene that encodes a cytosolic enzyme, N-acetyltransferase 8B, which plays a key role in the detoxification of xenobiotics, particularly aromatic amines. This detoxification process involves the conversion of these harmful compounds into more water-soluble forms, enabling their excretion. NAT8B also participates in the acetylation of various endogenous substrates, including drugs, neurotransmitters, and hormones, impacting their activity and metabolism. This gene is expressed in various tissues, including liver, lung, and kidney, reflecting its widespread involvement in detoxification and metabolic pathways.
NAT8B, also known as N-acetyltransferase 8B, is a cytosolic enzyme that plays a crucial role in the detoxification of xenobiotics, particularly aromatic amines, by catalyzing their acetylation. This process converts these potentially harmful compounds into more water-soluble forms, facilitating their excretion from the body. NAT8B also participates in the acetylation of various endogenous substrates, including drugs, neurotransmitters, and hormones, influencing their activity and metabolism. Its expression is found in various tissues, including liver, lung, and kidney, reflecting its widespread involvement in xenobiotic detoxification and metabolic processes.
NAT8B is also known as CML2, Hcml2, NAT8BP.
