NAT1
Description
The NAT1 (N-acetyltransferase 1) is a protein-coding gene located on chromosome 8.
NAT1, the human gene encoding N-acetyltransferase 1 (arylamine N-acetyltransferase), is one of two such genes in the human genome. It shares evolutionary similarities with the NAT2 genes found in mice and rats. The enzyme produced by NAT1 facilitates the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This process is crucial for metabolizing drugs and other foreign compounds (xenobiotics) and plays a role in folate breakdown. Multiple variations in the NAT1 gene have been observed, leading to the production of different isoforms.
NAT1 is also known as AAC1, MNAT, NAT-1, NATI.
Associated Diseases
- breast cancer
- glycogen storage disease due to lactate dehydrogenase H-subunit deficiency
- cancer
- alcohol sensitivity, acute
- nanophthalmia
- nanophthalmos 2
- microphthalmia, isolated, with coloboma 5
- congenital primary aphakia
- aniridia
- microphthalmia, isolated, with coloboma 10
