NANOS3
Description
The NANOS3 (nanos C2HC-type zinc finger 3) is a protein-coding gene located on chromosome 19.
NANOS3 is a crucial regulator of germ cell development, ensuring their undifferentiated state and preventing premature differentiation. It controls the spermatogonia cell cycle by extending the G1 phase, thus maintaining a pool of undifferentiated germ cells. This regulation is likely achieved through the repression of specific mRNA translation, which influences cell proliferation. NANOS3 also plays a protective role by suppressing both Bax-dependent and -independent apoptosis pathways, safeguarding the germ cell lineage. In early embryos, NANOS3 is essential for protecting migrating primordial germ cells (PGCs) from apoptosis, ensuring their survival and proper migration.
NANOS3 is also known as NANOS1L, NOS3, ZC2HC12C.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- partial chromosome Y deletion
- isolated congenital hypogonadotropic hypogonadism
- spinocerebellar ataxia type 32
- congenital bilateral absence of vas deferens
- isochromosomy Yp
- Kallmann syndrome
- spermatogenic failures 50
- spermatogenic failure 25
- spermatogenic failure, X-linked, 2
