NAAA

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Description

The NAAA (N-acylethanolamine acid amidase) is a protein-coding gene located on chromosome 4.

NAAA breaks down bioactive fatty acid amides into their corresponding acids, with a preference for N-palmitoylethanolamine, followed by N-myristoylethanolamine, then N-lauroylethanolamine and N-stearoylethanolamine, with weaker activity towards N-arachidonoylethanolamine and N-oleoylethanolamine. NAAA also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine.

NAAA is also known as ASAHL, PLT.

Associated Diseases

• hemoglobin E-beta-thalassemia syndrome
• hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
• microcytic anemia with liver iron overload
• primary familial polycythemia due to EPO receptor mutation
• alpha-thalassemia-myelodysplastic syndrome
• hemoglobin D disease
• alpha thalassemia-intellectual disability syndrome type 1
• hemochromatosis type 5
• delta-beta-thalassemia
• hemolytic anemia due to diphosphoglycerate mutase deficiency
• dominant beta-thalassemia
• gluthathione peroxidase deficiency
• hemoglobin C-beta-thalassemia syndrome