MYO1G
Description
The MYO1G (myosin IG) is a protein-coding gene located on chromosome 7.
MYO1G, also known as myosin 1G, is a protein encoded by the MYO1G gene in humans. It belongs to the class I unconventional myosins and is primarily found in hematopoietic tissues and cells. MYO1G localizes exclusively to the plasma membrane, depending on both its motor domain and tail domain. It regulates cell elasticity by interacting with the plasma membrane and cortical actin in Jurkat T-cells. MYO1G is a plasma membrane-associated class I myosin found in abundance in T and B lymphocytes and mast cells.
MYO1G, an unconventional myosin, plays a crucial role in immune responses by regulating T-cell migration and enhancing the detection of rare antigen-presenting cells. Its actin-based motor activity generates membrane tension, promoting a meandering search pattern in T-cells, which improves the chances of encountering rare antigens during lymph-node surveillance, ultimately leading to pathogen eradication. MYO1G also has a function in B-cells, where it regulates various membrane and cytoskeletal processes. Additionally, MYO1G is involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis, a process essential for the immune system's ability to engulf and destroy foreign particles.
MYO1G is also known as HA2, HLA-HA2, MHAG.
