MYO1C
Description
The MYO1C (myosin IC) is a protein-coding gene located on chromosome 17.
Myosin-Ic is a protein encoded by the MYO1C gene in humans. It belongs to the unconventional myosin family, which are actin-based molecular motors. The protein is found in the cytoplasm, with a unique N-terminal isoform also present in the nucleus. The nuclear isoform interacts with RNA polymerase I and II, playing a role in transcription initiation. The mouse ortholog of this protein is involved in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been identified for this gene. The related gene myosin IE, sometimes referred to as myosin IC in the literature, is a distinct locus on chromosome 19.
Myosin-Ic, also known as Myosin I beta, is an actin-based motor protein that plays a crucial role in intracellular movement. It binds to cellular membranes via its tail domain, facilitating the movement of membrane-bound compartments relative to actin filaments. This protein is involved in glucose transporter recycling in response to insulin, regulating the movement of intracellular vesicles containing GLUT4 to the plasma membrane. Myosin-Ic is also a component of the adaptation-motor complex in hair cells, the sensory cells of the inner ear. It acts as a mediator of adaptation in mechanoelectrical transduction within the stereocilia of vestibular hair cells. Additionally, Myosin-Ic binds to phosphoinositides, linking the actin cytoskeleton to cellular membranes.
MYO1C is also known as MMI-beta, MMIb, MyoIC, NMI, myr2.
Associated Diseases
- autosomal dominant nonsyndromic hearing loss
- hearing loss, autosomal recessive
- endometrial cancer
- allergic disease
