MYO16
Description
The MYO16 (myosin XVI) is a protein-coding gene located on chromosome 13.
MYO16, also known as unconventional myosin-XVI, is a motor protein that uses ATP to move along actin filaments. It plays a crucial role in intracellular movement, particularly in neuronal development. MYO16 interacts with various proteins, including the catalytic subunit of protein phosphatase 1 (PPP1CA/PPP1CC), the WAVE1 complex (CYFIP1 and NCKAP1), and the PI3K signaling pathway. This interaction facilitates the recruitment of the WAVE1 complex to PI3K, leading to actin cytoskeleton remodeling and neuronal morphogenesis. Additionally, MYO16 may contribute to the targeting of protein phosphatase 1 during brain development.
MYO16 is also known as MYAP3, MYR8, Myo16b, NYAP3, PPP1R107.
