MYO10

Description

The MYO10 (myosin X) is a protein-coding gene located on chromosome 5.

MYO10, also known as Myosin X, is a protein encoded by the MYO10 gene in humans. It is an actin-based motor protein that can localize to the tips of filopodia, finger-like cellular protrusions. MYO10 is broadly expressed in mammalian tissues, though at relatively low levels. Studies using knockout mice have shown that MYO10 plays crucial roles in embryonic development, including neural tube closure and eye development. Additionally, MYO10 has important functions in cancer invasion and growth. It is important to distinguish MYO10 from Myh10, which encodes the heavy chain of the class II myosin known as non-muscle myosin 2b. MYO10 is composed of a head, neck, and tail. The N-terminal head contains the myosin motor domain, which binds to actin filaments, hydrolyzes ATP, and generates force.

MYO10 is an actin-based motor protein that moves along actin filaments towards their plus ends. It is involved in intracellular transport, regulating cell shape, spreading, and adhesion. MYO10 stimulates the formation and elongation of filopodia, cellular protrusions that play a role in cell motility and sensing the environment. In neurons, MYO10 traffics the actin-remodeling protein VASP to the tips of filopodia, promoting actin elongation and dendritic filopodia formation. MYO10 is also involved in the formation of the podosome belt in osteoclasts, specialized bone-resorbing cells.

MYO10 is also known as MyoX.

Associated Diseases

WES Whole Exome Sequencing