MYL12B
Description
The MYL12B (myosin light chain 12B) is a protein-coding gene located on chromosome 18.
MYL12B, the gene encoding the myosin light chain 12B protein, is also known as MLC-B or MRLC2. MYL12B is a regulatory light chain that controls the activity of nonmuscle myosin II. Phosphorylation of MYL12B enhances the ATPase activity of myosin II and promotes the assembly of myosin II filaments.
MYL12B plays a crucial role in regulating contractile activity in both smooth muscle and nonmuscle cells through phosphorylation. This phosphorylation triggers actin polymerization, particularly in vascular smooth muscle. MYL12B is also implicated in essential cellular processes like cytokinesis, receptor capping, and cell locomotion.
MYL12B is also known as MLC-B, MRLC2.
Associated Diseases
- dehydrated hereditary stomatocytosis
- Rh deficiency syndrome
- hemoglobin E-beta-thalassemia syndrome
- familial pseudohyperkalemia
- hemochromatosis type 5
- gluthathione peroxidase deficiency
- hemolytic anemia due to erythrocyte adenosine deaminase overproduction
- microcytic anemia with liver iron overload
- hemolytic anemia due to glutathione reductase deficiency
- megaloblastic anemia, folate-responsive
- hemoglobin D disease
- cryohydrocytosis
