MYCNOS
Description
The MYCNOS (MYCN opposite strand) is a ncRNA gene located on chromosome 2.
MYCNOS, also known as MYCN-binding protein, is a protein that in humans is encoded by the MYCNOS gene. It plays a role in regulating the stability of the MYCN protein, a key oncogene implicated in neuroblastoma, by inhibiting GSK3B-mediated phosphorylation of MYCN. This inhibition of phosphorylation stabilizes MYCN, potentially contributing to tumor growth.
MYCNOS is also known as MYCN-AS1, N-CYM, NCYM, NYCM.
Associated Diseases
- retinoblastoma
- cancer
- glioblastoma
- urinary bladder carcinoma
- nonpapillary renal cell carcinoma
- pachyonychia congenita
- microphthalmia with limb anomalies
