MYCN : MYCN proto-oncogene, bHLH transcription factor
Description
The MYCN (MYCN proto-oncogene, bHLH transcription factor) is a protein-coding gene located on chromosome 2.
The MYCN gene provides instructions for making a protein that plays a crucial role in tissue and organ development before birth. Animal studies indicate its necessity for normal development of limbs, heart, kidneys, lungs, nervous system, and digestive system. The MYCN protein acts as a transcription factor, controlling gene activity by binding to specific DNA regions and regulating the initial step of protein production (transcription). The MYCN gene is classified as an oncogene, meaning mutations in it can potentially transform normal cells into cancerous ones. It belongs to the Myc family of oncogenes, which play significant roles in regulating cell growth, division (proliferation), and programmed cell death (apoptosis).
MYCN positively regulates the transcription of MYCNOS in neuroblastoma cells.
MYCN is also known as FGLDS1, MODED, MPAPA, MYCNsORF, MYCNsPEP, N-myc, NMYC, ODED, bHLHe37.
Associated Diseases
- Feingold syndrome 1
- Neuroblastoma
- Megalencephaly-polydactyly syndrome
- Feingold syndrome type 1
- Retinoblastoma
- Feingold syndrome
