MTHFD2L
Description
The MTHFD2L (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like) is a protein-coding gene located on chromosome 4.
MTHFD2L, also known as bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, is an enzyme encoded by the MTHFD2L gene on chromosome 4. It resides in the inner mitochondrial membrane and is involved in the mitochondrial pathway for converting folate to formate. This enzyme utilizes NADP+ in its dehydrogenase/cyclohydrolase activity. Fluctuations in its activity have been linked to cytokine responses during viral infections and vaccinations. The MTHFD2L gene has nine exons and is highly conserved across mammals. It encodes a 340-amino acid protein that shares similarities with other folate-metabolizing enzymes like MTHFD2, MTHFD1, and MTHFD1L. MTHFD2L contains a mitochondrial targeting sequence and essential amino acids for its enzymatic activity. Three RNA transcript forms of MTHFD2L have been observed in brain and placenta, but their protein translation in vivo is yet to be confirmed. MTHFD2L is part of the tetrahydrofolate dehydrogenase/cyclohydrolase family and is expressed in various adult tissues. Its location within the mitochondria is specifically on the matrix side of the inner mitochondrial membrane. It plays a vital role in the mitochondrial folate metabolism pathway by converting folate to formate.
MTHFD2L is also known as -.
