MTA3
Description
The MTA3 (metastasis associated 1 family member 3) is a protein-coding gene located on chromosome 2.
MTA3 is a protein encoded by the MTA3 gene in humans. It is found in the nucleus and other cellular compartments and is a component of the NuRD complex, participating in gene expression. MTA3 expression is inversely related to MTA1 and MTA2 during mammary gland tumorigenesis, but it is also overexpressed in various human cancers. The human MTA3 gene has 20 exons and 19 alternatively spliced transcripts, predicting six proteins with varying lengths.
MTA3 is a component of the NuRD complex, which plays a role in chromatin remodeling. It helps maintain normal epithelial architecture by repressing SNAI1 transcription in a histone deacetylase-dependent manner, thus regulating E-cadherin levels. MTA3 also contributes to transcriptional repression by BCL6.
MTA3 is also known as -.
Associated Diseases
- endometrial cancer
- cancer
- gastroesophageal junction adenocarcinoma
- isolated asymptomatic elevation of creatine phosphokinase
- plasma fibronectin deficiency
