MTA2
Description
The MTA2 (metastasis associated 1 family member 2) is a protein-coding gene located on chromosome 11.
Metastasis-associated protein MTA2 is a protein encoded by the MTA2 gene in humans. MTA2 is the second member of the MTA family of genes and localizes in the nucleus as a component of the NuRD complex. Similar to MTA1, MTA2 functions as a chromatin remodeling factor that regulates gene expression. MTA2 is overexpressed in human cancer and its dysregulated levels are associated with cancer invasiveness and aggressive phenotypes. MTA2 was initially identified as an MTA1-like 1 gene (MTA1-L1) in 1999 and its role in gene expression was discovered through its association with the NuRD complex. The human MTA2 gene, located on chromosome 11q12-q13.1, contains 20 exons and seven transcripts, including three protein-coding transcripts that code for two polypeptides of 688 and 495 amino acids. The remaining four MTA2 transcripts are non-coding RNA transcripts.
MTA2 acts as a transcriptional coregulator and is a component of the histone deacetylase NuRD complex, which remodels chromatin.
MTA2 is also known as MTA1L1, PID.
