MST1R
Description
The MST1R (macrophage stimulating 1 receptor) is a protein-coding gene located on chromosome 3.
Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene. MST1R is also known as RON (Recepteur d'Origine Nantais) kinase, named after the French city in which it was discovered. It is related to the c-MET receptor tyrosine kinase.
== Interactions == MST1R has been shown to interact with Grb2.
MST1R, also known as RON, is a receptor tyrosine kinase that transmits signals from the extracellular matrix to the cytoplasm upon binding to MST1 ligand. This signaling plays a vital role in regulating various cellular processes such as survival, migration, and differentiation. When the ligand binds to the cell surface, it triggers autophosphorylation of RON's intracellular domain, creating docking sites for downstream signaling molecules. These downstream effectors, such as PI3-kinase subunit PIK3R1, PLCG1, or the adapter GAB1, are recruited by RON, activating signaling cascades including RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling is essential for wound healing, promoting epithelial cell migration, proliferation, and survival at the wound site. It also contributes to the innate immune response by regulating macrophage migration and phagocytic activity. Notably, RON can also initiate signals like cell migration and proliferation in response to growth factors other than MST1 ligand.
MST1R is also known as CD136, CDw136, NPCA3, PTK8, RON, SEA, p185-Ron.
