MSRB2
Description
The MSRB2 (methionine sulfoxide reductase B2) is a protein-coding gene located on chromosome 10.
Methionine-R-sulfoxide reductase B2, mitochondrial is an enzyme that in humans is encoded by the MSRB2 gene. The MRSB2 enzyme catalyzes the reduction of methionine sulfoxide to methionine.
MSRB2 is an enzyme that specifically reduces methionine (R)-sulfoxide back to methionine. This reduction can occur due to random oxidation following oxidative stress or as a post-translational modification on specific residues. During oxidative stress, MSRB2 plays a role in preserving mitochondrial integrity by decreasing reactive oxygen species build-up through its scavenging activity. This contributes to cell survival and protein maintenance.
MSRB2 is also known as CBS-1, CBS1, CGI-131, MSRB, PILB.
Associated Diseases
- Parkinson disease
- Alzheimer disease
- nail-patella syndrome
- tuberculosis
- pancreatic ductal adenocarcinoma
- cancer
