MSMB
Description
The MSMB (microseminoprotein beta) is a protein-coding gene located on chromosome 10.
Beta-microseminoprotein is a protein encoded by the MSMB gene. It is one of the three major proteins secreted by prostate epithelial cells and is present in seminal plasma at high concentrations. While primarily associated with the prostate, it is also secreted by epithelial cells in various organs including the liver, lung, breast, kidney, colon, stomach, pancreas, esophagus, duodenum, salivary glands, fallopian tube, corpus uteri, bulbourethral glands, and cervix. This wide distribution aligns with the origins of many late-onset cancers.
MSMB is a rapidly evolving protein, demonstrating structural similarity between human and porcine versions despite only 51% amino acid identity. Its C-terminus domain contains two β-sheets with unique structural characteristics. This rapid evolution is likely driven by either sexual selection or innate pathogen defense, with its wide distribution and fungicidal C-terminus suggesting a role for pathogen defense.
MSMB belongs to the immunoglobulin binding factor family and has been reported to possess inhibin-like properties, though this finding remains controversial.
MSMB is also known as HPC13, IGBF, MSP, MSPB, PN44, PRPS, PSP, PSP-94, PSP57, PSP94.
Associated Diseases
- prostate cancer
- cancer
- pachyonychia congenita
- linear atrophoderma of Moulin
- familial generalized lentiginosis
- Dowling-Degos disease 1
- familial progressive hyperpigmentation
- acroleukopathy, symmetric
- dyschromatosis symmetrica hereditaria
