MSL1
Description
The MSL1 (MSL complex subunit 1) is a protein-coding gene located on chromosome 17.
MSL1, also known as Male-specific lethal 1-like 1, is a non-catalytic component of the MSL histone acetyltransferase complex, which is essential for maintaining chromosome stability and genome integrity. The complex plays a role in gene dosage compensation by up-regulating genes expressed by the X chromosome. It also participates in gene dosage compensation by promoting the expression of the Tsix non-coding RNA.
MSL1 is a crucial component of the MSL histone acetyltransferase complex. It plays a vital role in regulating histone modifications, particularly H4K16ac, a mark linked to chromatin structure. MSL1 enhances MSL2's E3 ubiquitin ligase activity, leading to H2BK34Ub, which in turn stimulates H3K4me and H3K79me, ultimately promoting gene activation.
MSL1 is also known as MSL-1.
