MSH6

MSH6 gene is vital for DNA repair and is associated with Lynch syndrome, a hereditary cancer condition

Associated Diseases

Lynch Syndrome, Endometrial cancer familial, Mismatch repair cancer syndrome 3

Did you know

The MSH6 gene, a critical component of DNA repair processes, is linked to Lynch syndrome, an inherited cancer predisposition syndrome. MSH6 mutations can disrupt DNA mismatch repair, increasing the likelihood of developing certain cancers, notably colorectal and endometrial cancers. Lynch syndrome affects approximately 1 in 300 to 1 in 2,000 individuals in the general population, depending on the specific population studied. Early identification of MSH6 mutations through genetic testing is crucial for identifying individuals at risk of Lynch syndrome and implementing appropriate surveillance and preventive measures. Understanding the prevalence and significance of MSH6 mutations helps healthcare professionals tailor strategies for cancer prevention and management, offering affected individuals and their families opportunities for proactive care and support.