MSH2

MSH2 gene is essential for DNA repair and is linked to Lynch syndrome, a hereditary cancer syndrome

Associated Diseases

Lynch Syndrome, Mismatch repair cancer syndrome 2, Muir-Torre syndrome

Did you know

The MSH2 gene, a crucial component of DNA repair mechanisms, is associated with Lynch syndrome, a hereditary cancer syndrome. Mutations in MSH2 can disrupt DNA mismatch repair, leading to genomic instability and an increased risk of developing certain cancers, particularly colorectal and endometrial cancers. Lynch syndrome affects approximately 1 in 300 to 1 in 2,000 individuals in the general population, depending on the specific population studied. Early identification of MSH2 mutations through genetic testing is essential for identifying individuals at risk of Lynch syndrome and implementing appropriate surveillance and preventive measures. By understanding the prevalence and significance of MSH2 mutations, healthcare professionals can better tailor strategies for cancer prevention and management in affected individuals and their families.