MRPL41
Description
The MRPL41 (mitochondrial ribosomal protein L41) is a protein-coding gene located on chromosome 9.
MRPL41 is a gene that encodes a protein involved in protein synthesis within the mitochondria. The protein is a component of the large subunit of the mitochondrial ribosome, which is responsible for assembling proteins within the mitochondria. MRPL41 belongs to the YmL27 ribosomal protein family. Mitochondrial ribosomes are distinct from those found in the cytoplasm, having a higher protein-to-RNA ratio and lacking a 5S rRNA.
MRPL41 is a component of the mitochondrial ribosome large subunit, playing a role in apoptosis and cell cycle regulation. It enhances p53 stability, contributing to p53-induced apoptosis in response to growth inhibitory conditions. MRPL41 promotes p53 translocation to the mitochondria and can arrest the cell cycle at the G1 phase, potentially by stabilizing CDKN1A and CDKN1B (p27Kip1) proteins.
MRPL41 is also known as BMRP, MRP-L27, MRPL27, PIG3, RPML27, mL41.
Associated Diseases
- lysosomal storage disease
- cancer
- Alzheimer disease
- nonpapillary renal cell carcinoma
- colorectal cancer
- pancreatic ductal adenocarcinoma
- laryngeal carcinoma
- breast cancer
