MRPL28
Description
The MRPL28 (mitochondrial ribosomal protein L28) is a protein-coding gene located on chromosome 16.
MRPL28 is a protein that is encoded by the MRPL28 gene in humans. It is a component of the mitochondrial ribosome, specifically the 39S large subunit. Mitochondrial ribosomes are responsible for protein synthesis within mitochondria, the energy-producing organelles of cells. Mammalian mitochondrial ribosomes are composed of a small 28S subunit and a large 39S subunit, with a significant protein-to-rRNA ratio. MRPL28, as part of the 39S subunit, plays a role in protein synthesis within mitochondria. Interestingly, a portion of MRPL28 was initially identified due to its ability to recognize tyrosinase, an enzyme involved in melanin production, in a specific immune context.
MRPL28 is a protein involved in protein synthesis within mitochondria, specifically as part of the 39S large subunit of the mitochondrial ribosome. It is crucial for the assembly and function of this ribosomal subunit, which plays a vital role in translation, the process of converting genetic information into proteins. MRPL28's interaction with the OXA1L protein suggests its role in the assembly or proper functioning of the mitochondrial ribosome, possibly in facilitating the incorporation of proteins into the ribosome or maintaining its structural integrity. Additionally, its ability to recognize tyrosinase in an HLA-A24-restricted fashion indicates a potential role in immune responses, particularly in the context of melanoma.
MRPL28 is also known as MAAT1, bL28m, p15.
