MRGPRX4
Description
The MRGPRX4 (MAS related GPR family member X4) is a protein-coding gene located on chromosome 11.
MRGPRX4, or Mas-related G-protein coupled receptor member X4, is a protein encoded by the MRGPRX4 gene in humans.
This receptor is an orphan receptor, meaning its natural ligand is unknown. It likely plays a role in nociceptive neurons, which are responsible for pain sensation. MRGPRX4 may regulate the function and development of nociceptors, potentially influencing the perception and modulation of pain. Notably, it is strongly activated by enkephalins, indicating a possible involvement in opioid signaling pathways.
MRGPRX4 is also known as GPCR, MRGX4, SNSR6.
Associated Diseases
- neutrophil immunodeficiency syndrome
- hepatorenocardiac degenerative fibrosis
- renal cysts and diabetes syndrome
- Mayer-Rokitansky-Kuster-Hauser syndrome
- 46,XX ovotesticular disorder of sex development
- hyperparathyroidism 2 with jaw tumors
- tetragametic chimerism
- type 2 diabetes mellitus
- cancer
