MRGPRX3
Description
The MRGPRX3 (MAS related GPR family member X3) is a protein-coding gene located on chromosome 11.
MRGPRX3 is a protein encoded by the MRGPRX3 gene in humans. It is a member of the Mas-related G-protein coupled receptor family.
This receptor is an orphan receptor, meaning its natural ligand is unknown. It likely plays a role in the function of nociceptive neurons, which are responsible for the sensation of pain. MRGPRX3 may regulate the function and development of nociceptors, potentially influencing the perception or modulation of pain. It is known to be strongly activated by enkephalins, which are opioid peptides.
MRGPRX3 is also known as GPCR, MRGX3, SNSR1, SNSR2.
Associated Diseases
- neutrophil immunodeficiency syndrome
- hepatorenocardiac degenerative fibrosis
- renal cysts and diabetes syndrome
- Mayer-Rokitansky-Kuster-Hauser syndrome
- 46,XX ovotesticular disorder of sex development
- hyperparathyroidism 2 with jaw tumors
- tetragametic chimerism
- cancer
