MRE11
Description of MRE11
MRE11 is a protein that plays a crucial role in maintaining the stability of DNA in cells. It is involved in repairing damaged DNA and ensuring that genetic information is accurately transmitted from one generation to the next. MRE11 is part of a protein complex known as the MRN complex, which also includes RAD50 and NBS1 proteins. Together, these proteins form a molecular shield that protects DNA from damage and ensures its integrity.
Associated Diseases
Mutations in the MRE11 gene have been linked to several genetic disorders, including:
- Ataxia-telangiectasia-like disorder (ATLD): ATLD is a rare genetic disorder characterized by progressive neurological degeneration, immune system dysfunction, and increased cancer risk. It is caused by mutations in the MRE11 gene.
- Nijmegen breakage syndrome (NBS): NBS is another rare genetic disorder that affects DNA repair and immune function. It is also caused by mutations in the MRE11 gene.
- Breast cancer: Studies have shown that mutations in the MRE11 gene can increase the risk of breast cancer, particularly in women who carry certain inherited risk factors.
- Ovarian cancer: Similar to breast cancer, mutations in the MRE11 gene have been associated with an increased risk of ovarian cancer.
Did you Know ?
Approximately 1 in 100,000 people worldwide is affected by ATLD or NBS, which are caused by mutations in the MRE11 gene. These disorders are often diagnosed in childhood or adolescence and can have significant health implications throughout life.