MPZ : myelin protein zero

Description

The MPZ (myelin protein zero) is a protein-coding gene located on chromosome 1.

The MPZ gene provides instructions for producing myelin protein zero, the most abundant protein in myelin. Myelin acts as a protective sheath around nerves, enabling efficient nerve impulse transmission. MPZ is produced by Schwann cells, which wrap around peripheral nerves, connecting the brain and spinal cord to muscles and sensory cells. MPZ is vital for forming and maintaining myelin, acting as an adhesion molecule that binds myelin wraps together, ensuring proper myelin compaction.

MPZ is a crucial adhesion molecule that ensures proper myelination in the peripheral nervous system. It acts as a molecular glue, mediating adhesion between adjacent myelin wraps, ultimately driving the compaction of myelin around nerve cells.

MPZ is also known as CHM, CHN2, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, DSS, HMSNIB, MPP, P0.

Associated Diseases

• Charcot-Marie-Tooth disease, axonal, type 2I
• Charcot-Marie-Tooth disease, type 2J
• Charcot-Marie-Tooth disease, dominant intermediate D
• Hypertrophic neuropathy of dejerine-sottas
• Charcot-Marie-Tooth disease, type 1B
• Roussy-Lévy syndrome
• Neuropathy, congenital hypomyelinating, 2
• Roussy-Levy hereditary areflexic dystasia
• Charcot-Marie-Tooth disease type 1B
• Charcot-Marie-Tooth disease