MPHOSPH10
Description
The MPHOSPH10 (M-phase phosphoprotein 10) is a protein-coding gene located on chromosome 2.
The MPHOSPH10 gene encodes a protein that is phosphorylated during mitosis. It is located in the nucleolus during interphase and on chromosomes during the M phase. This protein is believed to be part of the U3 small nucleolar ribonucleoprotein complex, which plays a role in rRNA processing.
MPHOSPH10 is a component of the U3 small nucleolar ribonucleoprotein (snoRNP), a complex involved in the early cleavages during pre-18S ribosomal RNA processing. It is also part of the small subunit (SSU) processome, the initial precursor of the small eukaryotic ribosomal subunit. Within the nucleolus, the SSU processome assembles, bringing together various ribosome biogenesis factors, an RNA chaperone, and ribosomal proteins. These components work collaboratively to achieve RNA folding, modifications, rearrangements, and cleavage, while also ensuring targeted degradation of pre-ribosomal RNA by the RNA exosome.
MPHOSPH10 is also known as CT90, MPP10, MPP10P, PPP1R106.
