MOSPD3
Description of MSPD3
Myeloid-specific progestin and adipoQ receptor delta (MSPD3) is a protein encoded by the MSPD3 gene. It belongs to the G protein-coupled receptor (GPCR) superfamily and plays a crucial role in immune regulation and adipogenesis. MSPD3 is primarily expressed in myeloid cells, including neutrophils, macrophages, and dendritic cells.
Structurally, MSPD3 consists of seven transmembrane domains, an extracellular N-terminus, and an intracellular C-terminus. It interacts with various ligands, such as progesterone and the adipokine adiponectin, triggering intracellular signaling pathways that regulate immune function and metabolic processes.
Associated Diseases
Dysregulation of MSPD3 has been implicated in several diseases and disorders:
- Immune Disorders: MSPD3 plays a role in immune cell activation, differentiation, and migration. Its deficiency or abnormal expression can contribute to inflammatory diseases, such as rheumatoid arthritis and lupus.
- Metabolic Disorders: MSPD3 is involved in adipocyte differentiation and insulin sensitivity. Mutations in MSPD3 have been associated with obesity, type 2 diabetes, and cardiovascular disease.
- Cancer: MSPD3 has been found to regulate tumor growth and metastasis in certain cancers, including breast cancer and melanoma. Its expression levels may affect disease prognosis and therapeutic efficacy.
Did you Know ?
- MSPD3 deficiency in mice has been shown to lead to a significant decrease in the number of circulating neutrophils, highlighting its importance in neutrophil development and function.
