MOSPD2
Description
The MOSPD2 (motile sperm domain containing 2) is a protein-coding gene located on chromosome X.
MOSPD2 is an endoplasmic reticulum (ER)-anchored protein that facilitates the formation of contact sites between the ER and other organelles, including endosomes, mitochondria, and Golgi. These interactions are mediated by MOSPD2's binding to conventional and phosphorylated FFAT-containing proteins on the target organelles. Additionally, MOSPD2 directly interacts with lipid droplets (LDs) to form ER-LD contacts, contributing to LD homeostasis. This interaction involves an amphipathic helix in MOSPD2 that recognizes lipid packing defects on the LD surface. MOSPD2 also plays a role in cell migration, promoting the movement of primary monocytes and neutrophils in response to chemokines.
MOSPD2 is also known as -.
